Romero Figueroa, MarÃa del Socorro1; Diaz Montiel, Juan Carlos1; Avila JimÃ©nez, Laura1; Duarte Mote, JesÃºs1; ColÃn Ferreyra, Ma. del Carmen2; Montiel JarquÃn, Ãlvaro JosÃ©3
Introduction: Diet has been implicated in many mechanisms related to the development of carcinogenesis, including apoptosis, cell cycle differentiation, inflammation and angiogenesis
Objective: To evaluate the association of the pattern of food consumption with breast cancer in obese patients
Methods: Comparative cross-sectional study in 98 obese women with menopause and newly diagnosed breast cancer and 95 obese women without breast cancer, wmenopause. A semi-quantitative questionnaire of 116 items of food consumption frequency was applied, age, BMI, gyneco- obstetric history history, smoking and alcohol were evaluated. Adjustment of multivariate logistic regression models using the STATA V 11 software.
Results: The main finding was that patients who had a vitamin B2 intake below the recommendation had a 6.74-fold chance of developing breast cancer, with a value of p = 0.06 compared to women who had adequate intake Of vitamin B2. The regression model was adjusted for age, BMI, glucose, serum triglycerides and diet.
Discussion: The results show a marginally significant association between vitamin B2 intake below the recommendation with the presence of breast cancer. Findings similar to those reported by other authors, who found weak evidence of an inverse association between breast cancer risk and riboflavin intake. Methionine, vitamin B12, vitamin B6, riboflavin are involved in the metabolism of methyl groups.
Conclusions: The results of this study support the need to further strengthen efforts on processes to understand the complexity and problems of using individual estimates of individual nutrient intakes and the potential role of B vitamins as protectors against this Type of cancer.