Abstract

Author(s): Raffoul Orozco, Abdel Kerim; Colunga Lozano, Luis Enrique; Ávila González, Ana Elisa; García Cobian, Teresa Arcelia; Pascoe González, Sara; Rubio Arellano, Edy David

Introduction: Inulin is a prebiotic that could help as an alternative or preventive treatment of diseases such as obesity, hyperglycemia or diabetes mellitus and dyslipidemia, a strategy for its consumption is to offer it in a food of daily consumption as is the tortilla.

Objective: To evaluate the intake of corn tortillas enriched with inulin on a metabolic profile in patients with dyslipidemia and BMI> 25.

Methods: One arm clinical trial included 22 patients with overweight or obesity (BMI ≥25) and dyslipidemia; That they present an ingestion of at least 5 tortillas daily, which were changed by tortillas enriched with 1 gr of inulin for 90 days.

Results: Changes in serum glucose were shown, decreasing 10% compared to baseline (p> 0.016). Clinical tendency to decrease insulin and total cholesterol, rest without significant changes

Discussion: Clinical differences were found with a reduction in total cholesterol levels of 40 mg on average, but not statistically significant, which contrasts with previous inulin intake studies in which a statistically significant decrease in serum lipids such as LDL and / or Total cholesterol, it should be noted that the inulin used was Agave Tequilana Weber, which presents changes in its molecular structure versus other inulins, and in the present study the average consumption was 4.32 g / day against 7.4 g and up to 30 g / day in other studies. The resulting hypoglycaemic effect was statistically significant for patients without hyperglycemia or diabetes, the mechanism of action is by increased glucagon-like peptide type 1, on the other hand there were no changes in body weight although inulin usually makes changes in the intestinal microbiota, which usually leads to a decrease in overweight or obesity.

Conclusion: The daily consumption of corn tortillas added with 1 g of inulin lowers glycemia and shows a non-statistical tendency to decrease serum insulin and total cholesterol levels.