Abstract

Author(s): Barbosa, Andressa Carneiro dos Santos; Costa Fontinele, Renata Rodrigues; Holanda, Aldenora Oliveira do Nascimento; Soares de Oliveira, Ana Raquel; Araújo Sampaio, Fabiane; Silva Morais, Jennifer Beatriz; Soares Severo, Juliana; Borges da Silva, Benedito; Marreiro, Dilina do Nascimento; Mota Martins, Luana

Introduction: Breast cancer is a multifactorial disease involving imbalance between genetic, dietary and hormonal factors. Research has shown that overweight associated with various metabolic disorders, such as chronic low-grade inflammation, which seems to be involved in development and progression of breast cancer. The objective was to evaluate the relationship between adiposity parameters and serum concentrations of C-reactive protein in women with breast cancer.

Methods: Cross-sectional study with cases and controls, involving 68 women, aged between 20 and 59 years, divided into two groups: case (breast cancer, n = 34) and control (without breast cancer, n = 34). Body mass index and waist circumference measurements were performed. The determination of serum C-reactive protein was by enzymatic colorimetric method.

Results: The mean body mass index of women with breast cancer were 26.17 ± 4.91 kg/m² and 22.78 ± 1.36 kg/m² for the control (p <0.05). The average concentration of C-reactive protein of women with breast cancer were 2.33 ± 3.57 mg/L and 1.90 ± 0.89 mg/L for the control (p <0.05). There was a positive correlation between body mass index, waist circumference and serum concentrations of C-reactive protein (p=0.036 and p=0.009, respectively).

Conclusion: From data analysis, there is a possible influence of adiposity parameters on serum concentrations of C-reactive protein in women with breast cancer, highlighting the participation of body fat accumulation in the development